{"id":5690,"date":"2020-11-02T08:47:19","date_gmt":"2020-11-02T08:47:19","guid":{"rendered":"https:\/\/ncrfrontlinenews.com\/?p=5690"},"modified":"2020-11-02T08:47:19","modified_gmt":"2020-11-02T08:47:19","slug":"researchers-identify-new-drug-to-treat-covid-19-patients","status":"publish","type":"post","link":"https:\/\/ncrfrontlinenews.com\/?p=5690","title":{"rendered":"Researchers identify new drug to treat Covid-19 patients"},"content":{"rendered":"<p><strong>London:<\/strong> In the continuing fight against the novel Coronavirus, researchers have now identified a drug with the potential to provide treatment for Covid-19 close to a year after it turned into a pandemic.<\/p>\n<p>The study, published in the journal Cells, found that the approved protease inhibitor aprotinin displayed activity against SARS-CoV-2, the coronavirus that causes Covid-19, in concentrations that are achieved in patients.<\/p>\n<p>According to the researchers, aprotinin aerosols are approved in Russia for the treatment of influenza and could be readily tested for the treatment of Covid-19.<\/p>\n<p>Aprotinin inhibits the entry of SARS-CoV-2 into host cells and may compensate for the loss of host cell protease inhibitors that are downregulated upon SARS-CoV-2 infection.<\/p>\n<p>&#8220;The aprotinin aerosol has been reported to be tolerated extremely well in influenza patients. Hence, it may have a particular potential to prevent severe Covid-19 disease when applied early after diagnosis,&#8221; said study author Martin Michaelis from the University of Kent in the UK.<\/p>\n<p>&#8220;Aprotinin has previously been shown to inhibit TMPRSS2 gene and has been suggested as a treatment option for influenza viruses and coronaviruses. Herein, we investigated the effects of aprotinin against SARS-CoV-2,&#8221; Michaelis added.<\/p>\n<p>The findings showed that aprotinin displayed anti-SARS-CoV-2 activity in different cell types (Caco2, Calu-3, and primary bronchial epithelial cell air-liquid interface cultures) and against four virus isolates.<\/p>\n<p>&#8220;An approved aprotinin aerosol may have the potential for the early local control of SARS-CoV-2 replication and the prevention of Covid-19 progression to a severe, systemic disease,&#8221; the study authors noted.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>London: In the continuing fight against the novel Coronavirus, researchers have now identified a drug with the potential to provide treatment for Covid-19 close to a year after it turned into a pandemic. The study, published in the journal Cells, found that the approved protease inhibitor aprotinin displayed activity against SARS-CoV-2, the coronavirus that causes [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5691,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":{"0":"post-5690","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health"},"_links":{"self":[{"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/posts\/5690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5690"}],"version-history":[{"count":1,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/posts\/5690\/revisions"}],"predecessor-version":[{"id":5692,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/posts\/5690\/revisions\/5692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=\/wp\/v2\/media\/5691"}],"wp:attachment":[{"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5690"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ncrfrontlinenews.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}